1、What Causes Hypercalcemia? Here Are 7 Known Causes

The possible causes of high calcium levels include more than 25 diseases, as well as some medications, supplements, genes, and lifestyle factors.

2、Hypercalcemia

Hypercalcemia is a condition in which the calcium level in the blood becomes too high. Too much calcium in the blood can weaken bones and create kidney stones. It also can affect the heart and brain. Most often, hypercalcemia happens after one or more of the parathyroid glands make too much hormone.

3、Hypercalcemia: What It Is, Causes, Symptoms & Treatment

Hypercalcemia happens when you have higher-than-normal levels of calcium in your blood. It's usually caused by primary hyperparathyroidism or certain cancers.

Hypercalcemia (High Level of Calcium in the Blood)

A high calcium level may result from a problem with the parathyroid glands, as well as from diet, excessive vitamin D intake, cancer, or disorders affecting bone.

Hypercalcemia

Principal causes include hyperparathyroidism, vitamin D toxicity, and cancer. Clinical features include polyuria, constipation, muscle weakness, confusion, and coma. Diagnosis is by measuring serum ionized calcium and parathyroid hormone concentrations.

What Is Hypercalcemia? Causes, Levels, Symptoms

The most common cause of high calcium levels (hypercalcemia) is an overproduction of the parathyroid hormone or hyperparathyroidism. Hyperparathyroidism tends to be more common in women.

Causes

This is a rare, benign, autosomal dominant disorder of calcium metabolism caused by a mutation in the calcium-sensing receptor leading to a general calcium insensitivity [Turner, 2017; Zagzag, 2018].

What Happens If My Calcium in Blood Is High? Causes and Solutions

The most frequent cause of high calcium levels is primary hyperparathyroidism. This condition arises when one or more of your four parathyroid glands become overactive and produce excess parathyroid hormone release.

14 Causes of Hypercalcemia (High Blood Calcium)

High blood calcium may point to a serious illness, but you can also get it from overdosing on certain supplements. Learn here about the causes.

Hypercalcemia Causes, Symptoms, and Treatments

Hypercalcemia — also known as high calcium levels — happens when you have too much calcium in your blood. Although there are many causes for hypercalcemia, it can happen when you have a parathyroid disorder, a genetic condition, or your kidneys aren’t working properly.

Calcium, a essential mineral in the human body, plays a critical role in maintaining bone health, nerve signaling, muscle contraction, and blood clotting. excessively high levels of calcium in the blood, known as hypercalcemia, can lead to health issues—a condition often misunderstood as "calcium deficiency" in common parlance.

1. Causes:

• Excessive Intake: Prolonged use of calcium supplements or consuming calcium-rich foods (e.g., dairy products, soy products) can lead to overaccumulation of calcium.
• Disease States: Conditions such as hyperparathyroidism, vitamin D deficiency rickets, or certain cancers may elevate blood calcium levels.
• Kidney Dysfunction: Impaired renal function reduces the body’s ability to excrete excess calcium, resulting in hypercalcemia.

2. Symptoms:

• Bone-Related: Bone pain, increased fracture risk, and reduced bone density.
• Cardiovascular: Arrhythmias, hypertension, and calcification of blood vessels.
• Nervous System: Numbness in limbs, muscle cramps, fatigue, and confusion.

3. Diagnostic Methods:

• Blood Tests: Measurement of serum calcium, phosphorus, alkaline phosphatase, and parathyroid hormone (PTH) levels.
• Imaging Exams: X-rays, CT scans, or MRIs to detect bone abnormalities or tissue calcification.
• Renal Function Tests: Assessing kidney capacity to filter and excrete calcium.

4. Treatment:

• Lifestyle Adjustments: Limit high-calcium foods, avoid excessive sun exposure (to reduce vitamin D synthesis), and reduce caffeine/alcohol intake.
• Medication: Target underlying causes (e.g., drugs to inhibit PTH secretion for hyperparathyroidism or bisphosphonates for bone-related issues).
• Dialysis: For severe cases linked to renal failure, dialysis may be required to remove excess calcium.

5. Prevention:

• Balanced Diet: Diversify nutrient intake to avoid overreliance on calcium-rich foods.
• Regular Check-ups: Especially for older adults, routine blood tests can help detect hypercalcemia early.

6. Key Considerations:

• Hypercalcemia may mask symptoms of other diseases, so persistent symptoms warrant prompt medical evaluation.
• Individuals at higher risk (e.g., those with hyperparathyroidism or chronic kidney disease) should undergo regular monitoring.

hypercalcemia is a complex condition caused by factors ranging from excessive calcium intake and disease states to renal dysfunction. Timely medical intervention and healthy lifestyle habits are crucial for managing this disorder. Misinterpreting hypercalcemia as "calcium deficiency" underscores the importance of accurate diagnosis and personalized treatment.